![]() ![]() ![]() Csd5 is of interest because it is found exclusively in H. One of the non-enzymatic proteins, Csd5, was also identified in these screens. pylori have also reinforced these findings and identified proteins that function as PG hydrolases give rise to distinctly non-helical cell shapes when deleted. Since bacteria are encased in a cell wall, any form of bacterial growth, division, and change in cell shape requires an intricate coordination of PG hydrolases that cleave PG, as well as PG synthases that facilitates the rebuilding of the cell wall. In most bacteria, the shape of the organism is determined by the peptidoglycan (PG) cell wall, comprised of a meshwork of glycan chains held together by peptide crosslinks that surrounds the cytoplasmic membrane to provide protection from osmolysis. pylori maintains its shape, with the hope that novel therapies may come in the form of disrupting the helical conformation to prevent infection. Since then, the Salama lab has sought to better delineate the mechanisms that define how H. pylori colonization of the stomach is present in about half of the world’s population, and in a subset of infected people, causes chronic inflammation accountable for a variety of gastric disorders. Nina Salama (Human Biology Division) and her colleagues in 2010 showing for the first time that the bacterium’s helical shape helps it colonize the stomach. pylori is shaped like a corkscrew, or helix, and the bacterium’s helical shape has been shown to be crucial for its ability to thrive in the stomach. pylori) colonizes the human stomach and is responsible for a significant global cancer burden as the primary cause of stomach cancer. Viruses, Vaccines and Infectious Diseases.Institutional Partners & Collaborations. ![]() Vaccine and Infectious Disease Division.Subscribe to Oncology Insights Newsletter. ![]()
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